pentobarbital will lower the extent or effect of methadone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital decreases results of sufentanil SL by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of CYP3A4 inducers may perhaps lower sufentanil ranges an